HIFU is used to treat
HIFU is not a suitable treatment for
- Brain tumours
- Lung cancer
- Cancers in the pelvic area
- Cancer that has spread to the lymph nodes
- Skin cancers
- Head and neck cancers
Because the prostate is positioned deep within the pelvis, you have HIFU for prostate cancerby putting an ultrasound probe (transrectal probe) into your back passage (rectum). From that position, the ultrasound can direct beams more accurately at the prostate. Results from trials so far show that HIFU may be as successful in treating prostate cancer as treatment with radical prostatectomyor radiotherapy. But we also have to be sure that the long term results will be as good as surgery or radiotherapy. The treatment hasn't been around long enough for us to know that yet.
The National Institute for Health and Clinical Excellence (NICE)have issued guidelines for the treatment of prostate cancer. The guidelines say that HIFU should only be used as part of a clinical trial. You could be offered HIFU instead of surgery or radiotherapy for localised prostate cancer. Doctors have used it for cancer that has just been diagnosed, or for cancer that has come back in the prostate after earlier treatment (salvage treatment).
If you are invited to go on a trial of HIFU for prostate cancer, your doctors need to make sure you know
- What is involved in having the treatment
- That we don't know everything about side effects yet
- That we don't fully understand how long term effects of HIFU compare to other treatments
- What other treatment options there are
Doctors must also monitor all the patients who have HIFU so that we can learn more about side effects and long term benefits or drawbacks. You will sign a consent form to say that all these things have been explained to you before you have the treatment.
There is information about UK prostate cancer trials on our clinical trials database. Select 'prostate' from the dropdown menu of cancer types.
There have been trials in the UK using HIFU for renal cell (kidney) cancer. In one trial patients had HIFU and a week or two later they had an operation to remove their cancer. The doctors looked at the cancer cells they removed to see what effect the HIFU had. The other trial was for patients with more advanced cancer that could not be removed with an operation. The aim of these trials was to find out how well HIFU works for kidney cancer, and what the side effects are. The results have not yet been made available.
Primary and secondary liver cancer
HIFU has been looked at in trials for both primary liver cancer ( hepatocellular cancer, HCC) and cancer that has spread to the liver (secondary liver cancer).
Studies, mainly in China, have looked at treating small HCC's with promising results. But more research is needed, particularly randomised trials to see if using HIFU for primary liver cancer is better than standard treatments Researchers also want to find out if HIFU is helpful in combination with other treatments for primary liver cancer. And to see if HIFU helps control symptoms for advanced disease.
HIFU also appears to be helpful for some secondary liver cancers. But researchers in the UK and other countries continue to look into this.
Doctors in China have used HIFU to help relieve pain and other symptoms in people with advanced pancreatic cancer. It is not being used to cure pancreatic cancer. Both in the UK and China, surgeryis still the first choice of treatment for people with pancreatic cancer that has not spread to other parts of the body. If you are not fit enough to have surgery to cure your cancer, then HIFU treatment would not cure your cancer either.
Doctors in China have used HIFU to treat people with bladder cancer. But if the cancer comes back in the bladder then doctors in China use surgery as the standard treatment with regular follow up.